Introduction
This is an advanced guide and assumes a deep understanding of the boss's rotations and mechanics for the Hard Mode version of the Sanctum of Rebirth, found in Sanctum HM Mechanics Overview.
Presets and Relics
Vermyx, Brood Mother
⬥ Release all s
with 
Pre-fight
+ 
Phase 1
→ 
→ 
→ 
→ 
→ 
(
)
Coilspawn
→ (tc) + 
→ → 
→ 
→ → → s
Phase 2
r + → s → r → 
Coilspawn
→ 
→ 
→ 
→ 
→ 
→ → →
Phase 3
→ 
→ 
+ → 
→ 
→ 
Kezalam, the Wanderer
⬥ Release all s with
War's Retreat
s
Pre-fight (Moonstone Obelisk 1)
r + → → → → 
→ → s
Phase 1
→ → → 
→ 
→ s → r → (3t) 
→
Moonstone Obelisk 1
→ → → 
Phase 2
→ 
+ 
+ (8t) → (3t) + → 
→ → → 
+ click → → → → → → → → 
Moonstone Obelisk 2
→ → →
Phase 3
→ → + → → → → → → ()
Nakatra, Devourer Eternal
⬥ Release all s with
War's Retreat
s
Phase 1
r + → → → → → → → → s → (2t) r +
Phase 2
→ 
→ → → → (5t) + (8t) → + 
→ 
+ 
→
Phase 3
Nefthys 1
s → r + + → → → (3t) →
Nefthys 2
→ → ()
Prephase
+ → → →
Phase 4
Shadowsands
+ 
+ → (tc) → (tc) → (leave)
Nakatra
(2t tc) + → → + → s → r + → → → →
Example Kills
⬥ Vermyx 
⬥ Kezalam
⬥ Nakatra
Source & licence
By PvME contributors under CC BY-NC-SA 4.0. Navigation and typography adapted. Unavailable source links and contributor names are labelled. Embedded media has separate rights.
Copied on 10 Nov 2026. Not rechecked against the current game.
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