Introduction
This is an advanced guide and assumes a deep understanding of the boss's rotations and mechanics for the Hard Mode version of the Sanctum of Rebirth, found in Sanctum HM Mechanics Overview.
Presets and Relics
Vermyx, Brood Mother
⬥ Release all s
with 
Pre-fight
+ 
Phase 1
→ 
→ 
→ 
→ 
→ 
(
)
Coilspawn
→ (tc) 
→ 
→ → 
→ 
→ → s
Phase 2
+ r + → s → r →
Coilspawn
→ 
+ 
→ 
→ 
→ 
→ → 
→ 
→ s
Phase 3
r + 
→ 
→ 
→ → 
Kezalam, the Wanderer
⬥ Release all s with
War's Retreat
s
Enter the boss arena quickly so that your consumes the 
buff
Phase 1
r + → 4t s → 4t → → → 3t 
→ 
→ 
→ → → + 
md of pillar
Moonstone Obelisk 1
+ equip 
→ → 
+ → 
Phase 2
→ → → + → → → → → + → → 
Moonstone Obelisk 2
+ → → (do on Kezalam if obelisk dies)
Phase 3
→ → → → → → →
Nakatra, Devourer Eternal
⬥ Release all s with
⬥ This rotation assumes 
+ master attack cape perk
War's Retreat
s
Phase 1
r + → → → → → → → → s → r +
Phase 2
+ → 
→ → → → → s → r + → + 
→ 
+ 
→ →
If not yet phased → → → continue from below with available cooldowns
Phase 3
Nefthys 1
→ → → → + tick 2
Make certain you do not surge earlier, as this will null hits
Nefthys 2
→ → 
Prephase
4t → / → → 
Phase 4
Shadowsands
+ + → (tc) → (tc) → tc + (leave once it lands)
Nakatra
(2t tc) + → → + → s → r + → → → → → →
Example Kills
⬥ Vermyx 
⬥ Kezalam
⬥ Nakatra
Source & licence
By PvME contributors under CC BY-NC-SA 4.0. Navigation and typography adapted. Unavailable source links and contributor names are labelled. Embedded media has separate rights.
Copied on 10 Nov 2026. Not rechecked against the current game.
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