
Introduction
This is an advanced guide and assumes a deep understanding of the boss's rotations and mechanics for the Hard Mode version of the Sanctum of Rebirth, found in Sanctum HM Mechanics Overview.
Presets and Relics
⬥ Ranged ![]()

Vermyx, Brood Mother

War's Retreat
s![]()
Phase 1
r
+
→
+
→
→
→
→
→ ![]()
Coilspawn
Build 10
→
→
→
to Vermyx
Phase 2
→ improvise with
/
/
/
/
based on stacks
Coilspawn
Build 12
+ 3-7
→
→
to Vermyx
Phase 3
→
→
→
→
→
→
→
→ improvise
Kezalam, the Wanderer

War's Retreat
s![]()
Pre-fight (Moonstone Obelisk 1)
r
+
→
→
→
![]()
Phase 1
s
→ r
+
→
→
→
→
![]()
Moonstone Obelisk 1
→
→
/
→
→ ![]()
Phase 2
→
→
→
→
→
→ target moonstone +
→ target kezalam +
+
+
→ build 12
+ 3
→
→
→
→
→
→
/
if not phased
Moonstone Obelisk 2
→
→
→
→ ![]()
Phase 3
→
→
→
/
→ improvise based on stacks
Nakatra, Devourer Eternal

⬥ Start on the east side to benefit from ![]()
War's Retreat
s![]()
Phase 1
r
+
→
→
→
→
→
→
→
+
→
→
→
+
+
→ ![]()
Phase 2
→
→
→
→
→
→
→
→
→
→ improvise until phased →
+ ![]()
Phase 3
Nefthys 1
→
→
(may have to improvise based on stacks)
Nefthys 2
→
→
→
→ build adrenaline on Nakatra
Phase 4
Shadowsands
→
→
→
→ build
+
while doing this, ideally end on 3-7
or may have to improvise later
Note:
multiplies stack generation, be careful not to consume
on ![]()
Nakatra
→
→
→
→
→
→
→
→
→
→
→
→
/
/
+
Magic hits → improvise
Example Kills
⬥ Ranged ![]()
Source & licence
By PvME contributors under CC BY-NC-SA 4.0. Navigation and typography adapted. Unavailable source links and contributor names are labelled. Embedded media has separate rights.
Copied on 10 Nov 2026. Not rechecked against the current game.
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